Parvalbumin Is a Mobile Presynaptic Ca Buffer in the Calyx of Held that Accelerates the Decay of Ca and Short-Term Facilitation
نویسندگان
چکیده
Martin Müller,1,2 Felix Felmy,3 Beat Schwaller,4 and Ralf Schneggenburger1 1Laboratory of Synaptic Mechanisms, Brain-Mind Institute, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland, 2Graduate School of Neural and Behavioral Sciences, Universität Tübingen, 72074 Tübingen, Germany, 3Biology II, Department for Neurobiology, Ludwig-MaximiliansUniversity, 82152 Martinsried, Germany, and 4Unit of Anatomy, Department of Medicine, University of Fribourg, 1705 Fribourg, Switzerland
منابع مشابه
Parvalbumin is a mobile presynaptic Ca2+ buffer in the calyx of Held that accelerates the decay of Ca2+ and short-term facilitation.
Presynaptic Ca2+ signaling plays a crucial role in short-term plasticity of synaptic transmission. Here, we studied the role of mobile endogenous presynaptic Ca2+ buffer(s) in modulating paired-pulse facilitation at a large excitatory nerve terminal in the auditory brainstem, the calyx of Held. To do so, we assessed the effect of presynaptic whole-cell recording, which should lead to the diffus...
متن کاملDevelopmental expression of the Ca2+-binding proteins calretinin and parvalbumin at the calyx of Held of rats and mice.
Ca(2+)-binding proteins of the EF-hand family are widely expressed in the CNS, and contribute to intracellular Ca(2+) buffering in neurons. In nerve terminals, Ca(2+)-binding proteins are likely to regulate transmitter release probability and synaptic short-term-plasticity. Here, we investigated the developmental expression pattern of calretinin and parvalbumin at a large excitatory synapse, th...
متن کاملA limited contribution of Ca2+ current facilitation to paired-pulse facilitation of transmitter release at the rat calyx of Held.
Recent studies have suggested that transmitter release facilitation at synapses is largely mediated by presynaptic Ca(2+) current facilitation, but the exact contribution of Ca(2+) current facilitation has not been determined quantitatively. Here, we determine the contribution of Ca(2+) current facilitation, and of an increase in the residual free Ca(2+) concentration ([Ca(2+)](i)) in the nerve...
متن کاملRole of the calcium-binding protein parvalbumin in short-term synaptic plasticity.
GABAergic (GABA = gamma-aminobutyric acid) neurons from different brain regions contain high levels of parvalbumin, both in their soma and in their neurites. Parvalbumin is a slow Ca(2+) buffer that may affect the amplitude and time course of intracellular Ca(2+) transients in terminals after an action potential, and hence may regulate short-term synaptic plasticity. To test this possibility, w...
متن کاملFacilitation through buffer saturation: constraints on endogenous buffering properties.
Synaptic facilitation (SF) is a ubiquitous form of short-term plasticity, regulating synaptic dynamics on fast timescales. Although SF is known to depend on the presynaptic accumulation of Ca(2+), its precise mechanism is still under debate. Recently it has been shown that at certain central synapses SF results at least in part from the progressive saturation of an endogenous Ca(2+) buffer (Bla...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007